I. Basic Information
Generic Zita: Semaglutide
Rudzi: GLP-1 receptor agonist (yakareba-inobata glucagon-yakafanana peptide-1 analogi)
Routine of Administration: Subcutaneous jekiseni (kamwe pavhiki)
II. Zviratidzo uye Chimiro cheMvumo yeMumba
Zvakatenderwa Zviratidzo
Type 2 Diabetes Treatment (Yakatenderwa neNMPA):
Chiyero: 0.5 mg kana 1.0 mg, kamwe chete pavhiki.
Zviito: Inogadzirisa shuga yeropa uye inoderedza njodzi yemoyo.
Kufutisa/Kufutisa Kurapa
III. Mechanism of Action uye Efficacy
Core Mechanism: Inomutsa GLP-1 receptors, inononoka kubuda mudumbu, uye inowedzera kuguta.
Inoshanda pane hypothalamic appetite centre, inhibiting appetite.
Inovandudza insulin senitivity uye inogadzirisa metabolism.
Kurasikirwa Kwehuremu Kushanda (Kubva pamiyedzo yekiriniki yepasi rose):
Avhareji yekurasikirwa kwemasvondo e68: 15% -20% (pamwe chete nemararamiro ekupindira).
Vasiri vane chirwere cheshuga (BMI ≥ 30 kana ≥ 27 vane matambudziko):
Varwere vane chirwere cheshuga: zvishoma kuderera uremu mhedzisiro (inenge 5% -10%).
IV. Inoshanda Population uye Contraindications
Applicable Population
International Standards (ona WHO):
BMI ≥ 30 (yakafuta);
BMI ≥ 27 ine hypertension, chirwere cheshuga, kana zvimwe zvirwere zvemetabolism (kuwandisa).
Kudzidzira Kwemumba: Inoda kuongororwa kwechiremba; pari zvino inonyanya kushandiswa pakugadzirisa uremu muvarwere vane chirwere cheshuga.
Contraindications
Nhoroondo yemunhu kana yemhuri ye medullary thyroid carcinoma (MTC);
Multiple endocrine neoplasia syndrome rudzi rwechipiri (MEN2);
Vakadzi vane pamuviri kana vanoyamwisa;
Zvirwere zvakanyanya mudumbu (zvakadai senhoroondo yepancreatitis).
V. Zvikonzero uye Njodzi
Zvinowanzoitika mhedzisiro (zviitiko> 10%):
Nausea, kurutsa, manyoka, kuvimbiswa (kuderedzwa nekushandisa kwenguva refu).
Kuderera kwekuda kudya, kuneta.
Njodzi Dzakakura:
Thyroid C-cell tumors (njodzi dzinoratidzwa muzvidzidzo zvemhuka, zvisati zvanyatsojeka muvanhu);
Pancreatitis, gallbladder chirwere;
Hypoglycemia (kuchenjerera kunodiwa kana ichishandiswa pamwe chete nemamwe majekiseni e hypoglycemic).
VI. Ikozvino Kushandiswa muChina
Nzira dzekuwana:
Diabetes Treatment: Kunyorerwa kubva kuchipatara chenguva dzose.
Kurapa Kurasikirwa Kwehuremu: Inoda kuongororwa kwakasimba nachiremba; mamwe madhipatimendi endocrinology ezvipatara zvepamusoro anogona kuzvirayira.
Njodzi Dzinobva Kunzira Dzisina Kurongeka: Mishonga inotengwa nenzira isiri yepamutemo inogona kunge iri yemanyepo kana kuchengetwa zvisina kufanira, zvichiunza njodzi yekuchengetedza.
VII. Mashandisiro Mazano
Nyatsotevedzera Chirevo chaChiremba: Shandisa chete mushure mekunge chiremba aongorora zviratidzo zvemetabolism uye nhoroondo yemhuri yekurapa.
Yakasanganiswa Mararamiro Kupindira: Mishonga inoda kusanganiswa nekutonga kwekudya uye kurovedza muviri kuti uwane mhedzisiro yakakwana.
Kuongorora Kwenguva Yakareba: Gara uchitarisa thyroid basa, pancreatic enzymes, uye chiropa uye itsvo basa.
Nguva yekutumira: Nov-03-2025