Testosterone undecanoate inopa yakakwirira kurapwa kuomerera kupfuura testosterone cypionate.

Zvigumisiro zvechidzidzo zvakaratidza kuti varume vakagamuchira majekiseni e testosterone undecanoate kwenguva refu vainyanya kuomerera pakurapa mushure megore re1 kupfuura varume vakagamuchira majekiseni e testosterone propionate kwenguva pfupi.
Ongororo yakadzokororwa yedata kubva kune varume vanopfuura 122,000 muUnited States yakaratidza kuti varume vaibatwa ne testosterone undecanoate (Aveed, Endo Pharmaceuticals) vaive nemitengo yakafanana yekuomerera mumwedzi yekutanga ye6 yekurapwa sevarume vaibatwa ne testosterone cypionate.Kuomerera kwemazinga kubva ku7 kusvika kumwedzi ye12, ine 8.2% chete yevarwere vanobatwa ne testosterone cypionate vachienderera mberi nekurapa kwemwedzi ye12 zvichienzaniswa ne41.9% yevarwere vanobatwa ne testosterone undecanoate.
"Uchapupu hunoratidza kuti mamwe maitiro ari nyore ekurapa kwe testosterone, akadai semajekiseni akareba-anoita, anokosha pakuda kwevarume vane kushaya testosterone kuti varambe vachirapa," akadaro Abraham Morgenthaler, MD, mubatsiri wepurofesa wekuvhiya.Helio akati akashanda mudhipatimendi reurology paBeth Israel Deaconess Medical Center paHarvard Medical School."Kune kukura kucherechedzwa kuti kushomeka kwe testosterone chinhu chakakosha chehutano uye kuti testosterone therapy inogona kuvandudza kwete zviratidzo chete asiwo hutano hunobatsira hwakadai sekuvandudza shuga yeropa, kuderedzwa kwemafuta uye kuwedzera mhasuru, manzwiro, density mapfupa uye chikonzero chisina kutaurwa. .kupererwa neropa.Nekudaro, izvi zvinobatsira zvinogona kuwanikwa chete kana varume vakarambira mukurapwa. ”
Morgenthaler nevamwe vaaishanda navo vakaita retrospective cohort yekuongorora data kubva kuVerdigm database, iyo ine ruzivo rwemagetsi rekodhi data kubva kuUS outpatient zvivako, kusanganisira avo vakatanga injectable testosterone undecanoate kana testosterone cypionate pakati pe2014 ne2018. Varume vane makore 18 uye kupfuura.Dhiyabhorosi yakaunganidzwa mumwedzi we6-increments kubva munaJuly 2019. Kurapa kwekuchengetedza kwakatsanangurwa senguva pakati pekugadzwa kusina kudarika kaviri yakakurudzirwa dosing nguva yevhiki dze20 ye testosterone undecanoate kana mavhiki e4 ye testosterone cypionate.Kutevedza kurapwa kwakaongororwa kubva pazuva rekutanga jekiseni kusvika pazuva rekuregedzwa, kuchinjwa kwemishonga, kana kupera kwekutanga kunyorerwa testosterone therapy.Testosterone isina-kuomerera muboka re testosterone undecanoate yakatsanangurwa sevhavha yemazuva anopfuura 42 pakati pekupedzisira kwekutanga kwekugadzwa uye zuva rekutanga rekugadzwa kwechipiri, kana kuti kupera kwemazuva anopfuura 105 pakati pekugadzwa kwemangwana.Kusaomerera muboka re testosterone cypionate kwakatsanangurwa senguva yemazuva anopfuura 21 pakati pekupera kwekugadzwa kumwe uye kutanga kweinotevera.Vatsvakurudzi vakaongorora kuchinja kwehuremu hwemuviri, BMI, kuwedzera kweropa, mazinga e testosterone, mazinga ezviitiko zvitsva zvemwoyo, uye njodzi kubva pamwedzi 3 isati yatanga jekiseni kusvika kumwedzi ye12 mushure mekutanga kurapwa.
Boka rekudzidza raive nevarume ve948 vanotora testosterone undecanoate uye varume ve121,852 vanotora testosterone cypionate.Pakutanga, 18.9% yevarume muboka re testosterone undecanoate uye 41.2% yevarume muboka re testosterone cypionate vakanga vasina kuongororwa kwe hypogonadism.Zvinoreva testosterone yakasununguka pakutanga yakanga yakakwirira kune varwere vanotora testosterone undecanoate vachienzaniswa nevaya vanotora testosterone cypionate (65.2 pg/mL vs 38.8 pg/mL; P <0.001).
Mumwedzi mitanhatu yekutanga, mazinga ekuomerera akanga akafanana mumapoka ose maviri.Kwenguva ye7 kusvika kumwedzi ye12, boka re testosterone undecanoate raiva nepamusoro pekunamatira kudarika boka re testosterone cypionate (82% vs 40.8%; P <0.001).Kuenzaniswa nemwedzi ye12, chikamu chepamusoro chevarume muboka re testosterone undecanoate vakaramba vasina testosterone therapy (41.9% vs 0.89.9%; P <0.001).Varume vanotora testosterone cypionate.
"Zvinotoshamisa ndezvokuti 8.2 muzana chete yevarume vakabaya testosterone cypionate vakaramba vachirapa mushure megore re1," akadaro Morgenthaler."Kukosha kwakaderera kweiyo inowanzoshandiswa testosterone therapy muUnited States zvinoreva kuti varume vasina testosterone vanobatwa zvisina kunaka."
Varwere vanobatwa ne testosterone undecanoate vaiva nekuchinja kukuru kwehuwandu hwe testosterone (171.7 ng/dl vs 59.6 ng/dl; P <0.001) uye testosterone yakasununguka (25.4 pg/ml vs 3.7 pg/ml; P = 0.001).Kuwedzera kwemwedzi ye12 kana ichienzaniswa nevarwere vanobatwa ne testosterone cypionate.Testosterone undecanoate yakaratidza kuderera kuduku mumazinga e testosterone akazara kupfuura testosterone cypionate.
Pamwedzi ye12, zvinoreva kuchinja kwehuremu, BMI, uye ropa rakafanana pakati pemapoka.Boka re testosterone undecanoate rakanga riine chikamu chepamusoro chevarume vakanga vachangobva kuongororwa erectile dysfunction uye kufutisa pakutevera, nepo boka re testosterone cypionate raiva nehuwandu hwevarume vakaonekwa kuti vane hypertension, congestive heart failure, uye kurwadziwa kusingaperi.
Kutsvakurudza kwakawanda kunodiwa kuti unzwisise kuti sei varume vakawanda vanobaya testosterone cypionate vanomira kurapwa mukati megore, Morgenthaler anoti.
"Tinogona kufunga kuti muchidzidzo ichi, testosterone undecanoate yakashandiswa muhuwandu hwepamusoro kwemwedzi ye12 nekuda kwekureruka kwemushonga wenguva refu, asi kuona kana izvi zvingave zvakakonzerwa nezvimwe zvinhu (zvakadai semari), kuvenga kazhinji kuzvirapa majekiseni, kushaikwa kwekuvandudzwa kwezviratidzo, kana zvimwe zvikonzero,” Morgenthaler akadaro.